INBDE (Integrated National Board Dental Examination) 2025 – 400 Free Practice Questions to Pass the Exam

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Question: 1 / 1180

What is the mechanism of action (MOA) for Subantimicrobial-dose Doxycycline (SDD)?

Promotes collagen synthesis

Inhibits osteoblasts

Inhibits MMPs (collagenases)

SDD works by inhibiting MMPs or matrix metalloproteinases, specifically collagenases. These enzymes play a role in breaking down collagen, a key component in connective tissue, and are often found in excessive amounts in periodontal disease. By inhibiting MMPs, SDD helps to prevent the breakdown of collagen and promote the regeneration of healthy connective tissue in the gums. Options A, B, and D are incorrect as they do not describe the specific mechanism of action for SDD in treating periodontal disease. Promoting collagen synthesis would not target the root cause of periodontal disease, which is MMP overactivity. Inhibiting osteoblasts would actually be counterproductive as these cells are responsible for bone growth and regeneration. And stimulation of gingival growth would not directly address the issue of MMP overactivity and collagen breakdown in the gums.

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Stimulates gingival growth

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